5. Morales DLS et al. “Outcomes of the PumpKIN trial of the Jarvik 2015 ventricular assist device.”
Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination
作者: Daniel Grupel et al. 年份: 2021 期刊: Vaccine DOI: 10.1016/j.vaccine.2021.08.025
证据等级: 待评估 IF: 待补充
中文核心摘要（150 字以内）：
PumpKIN试验（儿科机械循环支持创新）是一项评估Jarvik 2015左心室辅助装置在儿童心力衰竭患者中的多中心临床试验。试验纳入24名患者，年龄从新生儿到青少年。结果显示67%的患者成功达到主要终点，包括心脏移植或心肌恢复。装置安全性良好，无装置相关死亡。 主要内容 试验设计：…
关键词：Jarvik-2000, 待补充
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📖 英文原文摘要
Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020.
This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2.
Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series.
A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer.
The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.
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